stem cell research paper topics

Stem Cell Research & Therapy

Thematic series - open for submissions, stromal cells and progenitor cells for osteoarticular regeneration.

Organoids and Tissue/Organ Chips

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Stem cell therapy of COVID-19 and other respiratory diseases

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Adult stem cells in retinal diseases: where do we go from here?

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Metabolic switching, growth kinetics and cell yields in the scalable manufacture of stem cell-derived insulin-producing cells

Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation

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Fetal liver CD34 + contain human immune and endothelial progenitors and mediate solid tumor rejection in NOG mice

Authors: Teja Celhar, Xinyi Li, Yunqian Zhao, Hui Chien Tay, Andrea Lee, Hui Hua Liew, Edwin Kunxiang Shepherdson, Ravisankar Rajarethinam, Yiping Fan, Anselm Mak, Jerry Kok Yen Chan, Amit Singhal and Takeshi Takahashi

Human platelet lysate-cultured adipose-derived stem cell sheets promote angiogenesis and accelerate wound healing via CCL5 modulation

Authors: Yueh-Chen Chen, Er-Yuan Chuang, Yuan-Kun Tu, Chia-Lang Hsu and Nai-Chen Cheng

The impact of hypoxia preconditioning on mesenchymal stem cells performance in hypertensive kidney disease

Authors: Gurparneet Kaur Sohi, Naba Farooqui, Arjunmohan Mohan, Kamalnath Sankaran Rajagopalan, Li Xing, Xiang Y. Zhu, Kyra Jordan, James D. Krier, Ishran M. Saadiq, Hui Tang, LaTonya J. Hickson, Alfonso Eirin, Lilach O. Lerman and Sandra M. Herrmann

Mesenchymal stem cell therapy for therapy refractory complex Crohn’s perianal fistulas: a case series

Authors: A. J. M. Pronk, K. J. Beek, M.E. Wildenberg, W. A. Bemelman, J. Stoker and C. J. Buskens

Single high-dose intravenous injection of Wharton’s jelly-derived mesenchymal stem cell exerts protective effects in a rat model of metabolic syndrome

Authors: Alvin Man Lung Chan, Angela Min Hwei Ng, Mohd Heikal Mohd Yunus, Ruszymah Hj Idrus, Jia Xian Law, Muhammad Dain Yazid, Kok-Yong Chin, Mohd Rafizul Mohd Yusof, See Nguan Ng, Benson Koh and Yogeswaran Lokanathan

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Stem cells: past, present, and future

Authors: Wojciech Zakrzewski, Maciej Dobrzyński, Maria Szymonowicz and Zbigniew Rybak

Ethical issues in stem cell research and therapy

Authors: Nancy MP King and Jacob Perrin

Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors

Authors: Paola Romina Amable, Rosana Bizon Vieira Carias, Marcus Vinicius Telles Teixeira, Ítalo da Cruz Pacheco, Ronaldo José Farias Corrêa do Amaral, José Mauro Granjeiro and Radovan Borojevic

CAR T cells in solid tumors: challenges and opportunities

Authors: Faroogh Marofi, Roza Motavalli, Vladimir A. Safonov, Lakshmi Thangavelu, Alexei Valerievich Yumashev, Markov Alexander, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Mostafa Jarahian, Sepideh Izadi, Ali Hassanzadeh, Naghmeh Shirafkan, Safa Tahmasebi and Farhad Motavalli Khiavi

Stem cells: a potential treatment option for kidney diseases

Authors: Dongwei Liu, Fei Cheng, Shaokang Pan and Zhangsuo Liu

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Topical collection Stromal cells and progenitor cells for osteoarticular regeneration Edited by Christian Jorgensen Topical collection Organoids and Tissue/Organ Chips Edited by Albert J Banes and Rajashekhar Gangaraju

Thematic series Adult stem cells in retinal diseases: where do we go from here? Edited by Rajashekhar Gangaraju

Thematic series Stem cell therapy of COVID-19 and other respiratory diseases   Edited by Hong-Long James Ji, Michael A. Matthay and Yuanlin Song

Thematic series NK cells as the next option for cancer treatment   Edited by Michael O'Dwyer

Cross-journal collection Coronavirus research highlights

Thematic series Stem cells and gene editing Edited by Stephen H. Tsang

Cross-journal collection Pluripotent Stem Cells

Thematic series Regenerative neurology Edited by Simon Koblar and Anne Hamilton-Bruce

Thematic series Extracellular vesicles and regenerative medicine Edited by Jeffrey Karp, Kelvin Ng and Armand Keating

Cross-journal collection Mesenchymal stem/stromal cells – an update Edited by Richard Schäfer and Selim Kuci

Cross-journal collection Biology and clinical applications of stem cells for autoimmune and musculoskeletal disorders Edited by Christian Jorgensen and Anthony Hollander

Thematic series Functional imaging in regenerative medicine Edited by Timothy O'Brien and Rocky Tuan

Thematic series Emerging investigators Edited by Timothy O'Brien and Rocky Tuan

Thematic series Stem cells and genitourinary regeneration Edited by John D Jackson

Thematic series Cardiovascular regeneration Edited by Ronald Li

Thematic series Physical influences on stem cells Edited by Gordana Vunjak-Novakovic

Thematic series Stem cell research in the Asia-Pacific Edited by Oscar Lee, Songtao Shi, Yufang Shi and Ying Jin

Thematic series Clinical applications of stem cells Edited by Mahendra Rao

Review series Immunology and stem cells Edited by Christian Jorgensen

Review series Epigenetics and regulation

Review series Stem cell niche

Review series Induced pluripotent stem cells

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Stem Cell Research & Therapy: 10th Anniversary

To mark the 10th year anniversary, we have reviewed the milestone achievements and highlighted some of the best content selected by our Editors-in-Chief and Associate Editors. Read more here .

Editors-in-Chief

Rocky S Tuan, The Chinese University of Hong Kong, Hong Kong SAR, China  Timothy O'Brien, University of Galway, Ireland

Journal submission information

Before you submit your manuscript to Stem Cell Research & Therapy , please ensure you have read and noted the below: 

• Authors are requested to provide institutional email addresses. At the minimum, at least the corresponding author and submitting author should provide an institutional email address.
• Image integrity and standards: Cropped gels and blots can be included in the main text if it improves the clarity and conciseness of the presentation. In such cases, the cropping of the blot must be clearly evident and must be mentioned in the figure legend. Corresponding uncropped full-length gels and blot must be included in the supplementary files. These uncropped images should indicate where they were cropped, be labelled as in the main text and placed in a single supplementary figure. The manuscript's figure legends should state that 'Full-length blots/gels are presented in Supplementary Figure X'. Further information can be found under 'Digital image integrity' which are detailed on our  Standards of Reporting  page.
• Authors should clearly declare in the Acknowledgement Section if there is any work that was outsourced or data not collected by authors. 
• Authors might be asked to provide original source data (raw data / original data / individual data points) if the reviewers or editors have any question.
• Authors should provide these information in the ethics declaration if the study involve human participants, human material, human data, or animals: (1) Title of the approved project; (2) Name of the institutional approval committee or unit; (3) Approval number; (4) Date of approval. Authors might be asked to provide ethics approval documents if the reviewers or editors have any question. 

Aims and scope

Stem Cell Research & Therapy is the major forum for translational research into stem cell therapies. An international peer-reviewed journal, it publishes high-quality open access research articles with a special emphasis on basic, translational and clinical research into stem cell therapeutics and regenerative therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries, reports and methods.

Topics covered include, but are not limited to: 

• Adult stem cells
• Animal models
• Biophysics and mechanobiology
• Cancer stem cells
• Cell culture and manufacture
• Clinical studies
• Disease modeling and drug screening
• Embryonic stem cells
• Ethical, legal and social aspects
• Genetics and epigenetics
• Genomics/proteomics/metabolomics
• Induced pluripotent stem cells
• Regenerative medicine
• Stem cell differentiation, proliferation and migration
• Stem cell therapy/transplantation
• Technologies
• Tissue engineering and biomaterials

Announcing the launch of In Review

Stem Cell Research & Therapy , in partnership with Research Square, is now offering  In Review.  Authors choosing this free optional service will be able to:

• Share their work with fellow researchers to read, comment on, and cite even before publication
• Showcase their work to funders and others with a citable DOI while it is still under review
• Track their manuscript - including seeing when reviewers are invited, and when reports are received 

Editors' quotes

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• v.14(6); 2020 Jun 9

Creating Opportunities to Advance Stem Cell Science: 2019–2020 Year in Review

While COVID-19 is the story of 2020, the story of our society over the past year has been about staying mission-focused, connecting the community, pushing science and translation forward, and responding to the needs of a diverse membership amidst the current challenge. Together, we have shown international leadership in scientific communications and programming, advocacy, and public education. Most importantly, the stem cell field continues to advance rapidly in both mechanistic understanding of disease and the translation of discovery into new therapies for so many devastating yet unsolved human diseases. Basic science discoveries in this area have matured to gain significant commercial investment in the last year for diabetes, Parkinson’s disease, heart failure, muscular dystrophies, and cancer, to name a few. Rigorous clinical and pre-clinical trials are advancing based on transplanting stem cells, reprogramming resident cells, discovering new drugs using stem cells, and delivering missing genes or gene editing machinery through novel gene therapy vectors. The important inflection point our field is experiencing makes me more hopeful than ever that stem cell biology and regenerative medicine will lead, in the not so distant future, to a world where we no longer have to accept the suffering of millions but instead can offer real cures.

Leading Development of International Guidelines for Stem Cell Research

As the science and clinical efforts progress, it is critical that we move with urgency but also great care and rigor, with careful consideration of ethics and the safety of the patients we serve. Since the release of the 2016 ISSCR “Guidelines for Stem Cell Research and Clinical Translation,” the field has advanced rapidly. Accordingly, an ISSCR task force led by Robin Lovell-Badge, Francis Crick Institute, UK is updating the ISSCR’s guidelines to address important scientific, ethical, and regulatory issues, including embryo models, organoids, chimeras, genome editing, and the regulation and economics of cell therapies. Revised guidelines will be available in early 2021, once again setting an international standard for excellence in stem cell research and clinical translation.

Complementing this initiative, the ISSCR and the Guangzhou Institute of Biomedicine and Health held a two-day workshop in Guangzhou, China in December 2019. The workshop focused on the regulation and application of gene-editing technology and the oversight of experimental treatments including patient protection and the governance of clinical trials. The meeting fostered an international dialog and exchange of information and ideas that will continue.

Communicating Impactful Stem Cell Research

Stem Cell Reports , the ISSCR’s open-access, online journal, has continued to publish impactful stem cell research while serving the stem cell community. In the last 12 months, the journal has published primary research Articles, Reviews, and Perspectives across a breadth of stem cell science—from fundamental research to translational discoveries happening in laboratories across the world.

We will soon be launching a Special Issue on Nuclear Architecture , a collection of original Reviews and primary research on the regulation and impact of chromatin structure in stem cells. The journal also has expanded its efforts to identify and highlight important ethical, political, or scientific issues within the stem cell or broader scientific community through Commentaries and Forum articles in our Society Pages. As always, we will be publishing our “Best of” issue in June so be sure to check the Stem Cell Reports website to see some of the editor’s favorite articles from the past 12 months.

Stem Cell Reports is important to the society and its education and outreach efforts with a percentage of the author publication charges supporting various initiatives including international public policy initiatives, educational efforts, career development programs, and public outreach. These important activities on behalf of members and the stem cell community could not take place without this vital support.

Sharing Excellence in Scientific Programs

Shaping the 2020 ISSCR annual meeting into a virtual experience required a monumental effort from our speakers and staff and represented a leap of faith from our sponsors, exhibitors, and attendees to support this new model. The 2020 program will be robust and engaging, though the delivery will be quite different from our successful ISSCR 2019 gathering in Los Angeles, California , US. The 2019 annual meeting drew nearly 4,000 attendees, 207 plenary and concurrent talks, and 1,400 poster presentations that covered the breadth of stem cell science and its applications.

We were pleased to translate nearly all of the programming into a virtual format for 2020 while keeping the registration fees extremely low for the community. Throughout seven plenary sessions, we are highlighting the increasing ability to perform mechanistic science and therapeutic discovery using technologies including human organoids, single-cell studies, and advanced computational approaches leveraging machine learning and artificial intelligence. We have continued to emphasize the valuable opportunities associated with the annual meeting available to young scientists that include being chosen as an abstract-selected speaker for a plenary or a concurrent session. The society also has designed sessions specifically for trainees, early-career scientists, and women in science that allow them to explore myriad career opportunities and enhance their professional development, and facilitate networking with senior researchers. Supporting the next generation of stem cell scientists through meaningful education and leadership opportunities remains a vital component of the society’s mission.

This year, we have incorporated parallel, theme-based tracks, which include Cellular Identity, Clinical Applications, Tissue Stem Cells and Regeneration, and Modeling Development and Disease. The Business of Discovery workshop is a new program this year and driven by the needs of our members to better understand how to take ideas from the bench to the market. Additionally, our “virtual” poster hall will allow attendees to view posters, listen to brief audio highlights, and communicate directly with the presenter through a dedicated chat.

The creation of focused themes and the growing emphasis on education in the commercialization of stem cell-based therapies emerged from approaches developed by the Task Force on Future Annual Meetings Strategy. Led by incoming ISSCR President Christine Mummery, Leiden University Medical Center, the Netherlands, and Lucy O’Brien, Stanford University, US, the group met in 2019 to evaluate how to continue to adapt our meeting as the field and the needs of the stem cell community evolve. Further, consistent with the society’s investment in recognizing excellence in stem cell science, the board of directors established two new awards that will be given for the first time during this year’s meeting. The ISSCR Momentum Award is given to an investigator whose innovative research has established a major area of stem cell-related research, while the ISSCR Achievement Award recognizes the transformative body of work that has had a major impact on the field of stem cell research or regenerative medicine.

Developing intimate meetings that bring together the world’s leading experts in a specific area of stem cell science remains a key mission of the ISSCR. In September 2019, the ISSCR hosted “Stem Cell Research: Present and Future” in Seoul, Korea in connection with the Korean Society of Stem Cell Research meeting. In November, “From Stem Cell Biology to New Therapies” featured leaders in translational research from academia and industry in Toronto, Canada with co-sponsor BlueRock. We will continue to consider how we will move forward with these International Symposia with programs planned in China, France, Japan, and the US over the next 16 months. Given our experience going virtual with the annual meeting, we are exploring the potential to continue regional meetings in a more virtual fashion if needed.

Advocating for Science-Based Policies

The ISSCR has strengthened its focus on international public policy including advocating to improve the regulation of unproven and unapproved stem cell-based interventions. Google’s new global policy to ban advertising for speculative medical products, including unproven stem cell treatments, represents a significant advocacy achievement this year. The policy sends a strong message to rogue clinics, improves the public discourse regarding stem cell research, and aligns with the ISSCR’s ongoing efforts to inform the public about the state of stem cell research. This year, the ISSCR joined an international effort to develop recommendations for the World Health Organization to strengthen the regulation and enforcement of unproven stem cell treatments. The society also urged regulatory authorities in the UK and Brazil to increase enforcement for the marketing of unproven stem cell-based products and strengthen the regulation of stem cell-based products, respectively.

The ISSCR published an Informed Consent Standard for Stem Cell Based Interventions to establish a professional standard for the information that needs to be provided to adequately inform patients about the risks and benefits of stem cell-based treatments. This resource builds on A Closer Look at Stem Cells , which is the society’s public education website for stem cell research. Finally, the society released a public warning about clinics offering stem cell “treatments” for COVID-19 to clarify that there are currently no approved stem cell-based therapies for COVID-19.

I joined other scientists and experts in Washington, D.C. for the ISSCR’s first Advocacy Day on Capitol Hill. The ISSCR met with policymakers to voice concerns regarding the new restrictions on research using fetal tissue and the proliferation of clinics selling unproven stem cell “treatments” and to support biomedical research funding. The importance of fetal tissue research, in particular, remained front and center during these meetings and throughout the year as the society led a coalition of 100 scientific organizations to urge the US administration to lift restrictions on fetal tissue research . The current policy has stymied the important and irreplaceable use of fetal tissue for understanding human development in a way that can be leveraged for human disease, as well as research using mice with humanized immune systems, particularly for COVID-19 studies.

In connection with Capitol Hill Advocacy Day activities, the ISSCR held its first liaison meeting with the US Food and Drug Administration (FDA) Center for Biologics Evaluation and Research (CBER) to discuss the use and regulation of stem cell-based products. The society anticipates meeting with the FDA annually and has plans to host similar meetings internationally when safe travel resumes.

Creating a More Informed Public

In 2019, the ISSCR launched an Education Committee that is assembling a syllabus and learning guide to teach undergraduate students, early graduate students, and medical students the core concepts of stem cell biology. This blueprint for an introductory course will explore how stem cells are being translated for clinical application and the corresponding ethical questions and is expected by the end of this year.

A Closer Look at Stem Cells , the society’s public-facing website, is designed to introduce the public to stem cell biology and provides patients with the resources they need to understand cell therapies and potential treatments. In 2019, unique visitors to the site grew 67% to nearly 500,000. The society has expanded the resources on this website by translating some of the disease fact sheets prepared by the Clinical Translation Committee and adding a new resource for parents-to-be about cord blood banking and donation .

Responding to Global Member Needs

Lastly, this year the society quickly responded to the needs of our members amid the COVID-19 crisis. What started as a dedicated resource page on the ISSCR website that collected global information and resources about COVID-19 and encouraged others to connect and share evolved into a survey of the international stem cell field. The results of the survey provided valuable insights around how scientists were coping and working during the crisis. The discovery that many laboratories had begun working on COVID-19 led the ISSCR to establish an ongoing series of networking meetings to connect members across the world and to launch a Slack channel to help facilitate collaboration. I am proud of how so many stem cell biologists are leveraging their knowledge and expertise to help in the fight against this global pandemic, and the ISSCR is helping them to network in ways leading to valuable collaborations.

The past 12 months serving as your president have been rewarding and challenging, but with every crisis comes new opportunity. It has been a year full of exciting achievements in stem cell research and new firsts for the society as we adapt to ensure that connections and communication continues in our field despite the new “normal.” I am confident our brightest days are ahead and together we will achieve our goal of stem cell biology and regenerative medicine alleviating human suffering. Thank you for your support of the ISSCR and the furtherance of the society’s mission.

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Stem cells: past, present, and future

Affiliations.

• 1 Department of Experimental Surgery and Biomaterials Research, Wroclaw Medical University, Bujwida 44, Wrocław, 50-345, Poland. [email protected].
• 2 Department of Conservative Dentistry and Pedodontics, Krakowska 26, Wrocław, 50-425, Poland.
• 3 Department of Experimental Surgery and Biomaterials Research, Wroclaw Medical University, Bujwida 44, Wrocław, 50-345, Poland.
• PMID: 30808416
• PMCID: PMC6390367
• DOI: 10.1186/s13287-019-1165-5

In recent years, stem cell therapy has become a very promising and advanced scientific research topic. The development of treatment methods has evoked great expectations. This paper is a review focused on the discovery of different stem cells and the potential therapies based on these cells. The genesis of stem cells is followed by laboratory steps of controlled stem cell culturing and derivation. Quality control and teratoma formation assays are important procedures in assessing the properties of the stem cells tested. Derivation methods and the utilization of culturing media are crucial to set proper environmental conditions for controlled differentiation. Among many types of stem tissue applications, the use of graphene scaffolds and the potential of extracellular vesicle-based therapies require attention due to their versatility. The review is summarized by challenges that stem cell therapy must overcome to be accepted worldwide. A wide variety of possibilities makes this cutting edge therapy a turning point in modern medicine, providing hope for untreatable diseases.

Keywords: Differentiation; Growth media; Induced pluripotent stem cell (iPSC); Pluripotency; Stem cell derivation; Stem cells; Teratoma formation assay; Tissue banks; Tissue transplantation.

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The authors declare that they have no competing interests.

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Stem Cell Differentiation and Applications

Dear Colleagues,

Stem cells have been used to generate new cells to replace damaged organs or tissues, and to evaluate the cell-type-specific disease mechanisms and genetics involved in the development of diseases and disorders. Pluripotent stem cells (PSCs) allow researchers to create in vitro disease modeling using patient-specific PSCs and to develop patient-specific therapies. We are pleased to invite you and your co-workers to submit your original research articles reporting on stem cell-based disease modeling, engineering, and therapy, including the molecular and pathophysiological mechanisms underpinning its development. We encourage the submission of original manuscripts and review articles spanning basic to clinical research, including pharmacological interventions to prevent and/or ameliorate disease.

Dr. Hiroyuki Hirai Dr. Haiyun Pei Dr. Atsushi Asakura Topic Editors

• embryonic stem cells
• induced pluripotent stem cells
• organoid, somatic stem cells
• stem cell differentiation
• stem cell therapy
• tissue-specific stem cells

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100 Stem Cell Research Topics + Examples

Are you looking for stem cell research topics? StudyCorgi has compiled a list of stem cell topics suitable for a research paper, essay, presentation, thesis, and other assignments. Our proposed titles go beyond examining the pros and cons of stem cell research and therapy and provide many fresh insights on this subject. We hope that our list will give you inspiration for developing your own project ideas.

🏆 Best Stem Cell Research Topics

🔎 easy stem cell research paper topics, 🎓 most interesting stem cell research paper topics, 💡 simple stem cell research topics for research paper, ❓ stem cell research questions.

• Advantages and Disadvantages of Stem Cell Research
• Stem Cell Research Justification and Benefits
• Pros and Cons of Stem Cell Research
• Ethical Issues in Stem Cell Research
• Stem Cell Debate: Advantages and Disadvantages of Stem Cell Technology
• Bio Ethics and Stem Cell Research
• Theories of Aging and Stem Cell Aging
• Sources Credibility in Internet Information About Stem Cells Research The standards for identifying a valid source about stem cell research are website layout, details of the topic’s explanation, references to scientific papers, etc.
• Brainstorm: Stem Cells Research Stem cells can function as any other type of cell in the body. They are important in the early stages of the body’s development, as they form the human body.
• Stem Cell: Environmental Science Stem cells are the type of cells that are really able to distinguish into types of cells, but they as well maintain the ability to renew all the way through the cell division.
• Stem Cells and Related Ethical Controversy The controversy of stem cells arises from the fact that a human embryo has to be destroyed to extract the stem cell.
• Ethical and Legal Regulation of Human Tissues and Stem Cells Research in the European Union Major advances in biological sciences have yielded new ways of tackling various environmental and health problems.
• Stem Cell Research as Ethical Health Care Issue In stem cell research, respect for autonomy involves the relationship between scientific research and the public through an emphasis on the importance of research.
• Stem Cells Research for the Cure of Cerebral Palsy The use of stem cells to cure cerebral palsy involves the introduction of the cells to the affected brain region so that they could grow and enable the part of the brain.
• Debate on Stem Cell Development from Human Embryo Several ethical debates have been conducted in the past concerning the development, utilization, and obliteration of human embryos.
• Stem Cells: Definition and Research Articles’ Analysis The purpose of this report is to define stem cells and assess the research on stem cells by analyzing and summarizing six scholarly articles.
• Use of Adult Stem Cells in Medicine The use of adult stem cells can lead to severe unintended outcomes which might compromise their application and acceptance.
• Stem Cell Therapy in the Treatment of Heart Disease Stem cell therapy is a viable strategy in treating heart disease, but it is still undergoing research; therefore, healthcare professionals should be cautious in pursuing it as a treatment option.
• Embryonic Stem Cell Research and Government Funding This paper discusses the values of embryonic stem cell research and whether it is appropriate for the government to finance it.
• Stem Cell Research: Ethical Nursing Principle The ethical nursing principle is directly violated by stem cell research since some nurses consider a human embryo to be a patient and cannot perform actions that will harm it.
• Human Embryonic Stem Cell Research In the world of bioethics the discussion on human embryonic stem cell research has resulted in a heated debate, from Washington D.C. and to the other parts of the United States of America.
• Fetal Rights vs. Stem Cell Research The rise of genetics as a scientific discipline had proven that the answers to social, political, and cultural problems lay exclusively in the field of biology.
• Stem Cell Research. Fetal Rights vs. Science The concept of the scientific study of the next stage of development, the fetus, which resulted from abortion, is unthinkable and unethical.
• California Is Crazy About Stem Cells The research on stem cells and their use in treating different conditions as well as associated debates have become very popular during recent years.
• Implementing Cost-Effective Stem Cell Innovation The purpose of the paper is to explore the broader issues that impact clinical trials of stem cell research and treatment in general.
• Adipose Stem Cells for Tissue Regeneration “Adipose stem cells: Biology and clinical applications for tissue repair and regeneration” describes the whole process of recovery in detail.
• Human Adult Versus Embryonic Stem Cells Study The controversies of human stem cell research and therapy has led to many governments taking considerable legislative actions that would severely regulate the field.
• Adult Stem Cell Research, Its Present and Future This analytical treatise attempts to explicitly review the controversies surrounding stem cell research to understand its current position in society.
• Stem Cell Research Essay: Research Ethics, Pros and Cons, and Benefits Looking at the benefits and shortcomings presented by stem cell research, one is left in a dilemma whether to support it or advocate for its discontinuity.
• Alzheimer’s Disease and Stem Cell Research
• Cancer Stem Cell Metabolism and Potential Therapeutic Targets
• Stem Cell Research and Neurodegenerative Diseases
• The Apgar and Stem Cell Research
• Cancer Stem Cell Hierarchy in Glioblastoma Multiforme
• Myths About Embryonic Stem Cell Research
• Stem Cell Therapy: Medico-Legal Perspectives in Italy
• Neural Stem Cell Regulation by Adhesion Molecules Within the Subependymal Niche
• Stem Cell Therapy for Diabetes
• Hepatocellular Carcinoma: From Hepatocyte to Liver Cancer Stem Cell
• Stem Cell Research and the Catholic Church
• Agents That Inhibit Stem Cell-Resistant Chemotherapy
• The Stem Cell State in Plant Development and Response to Stress
• Stem Cell Donor Matching for Patients of Mixed Race
• Arguing for Embryonic Stem Cell Research
• MiRNAs Regulate Stem Cell Self-Renewal and Differentiation
• Stem Cell Therapy for Heart Failure
• The Extraocular Muscle Stem Cell Niche Is Resistant to Ageing and Disease
• Embryonic Stem Cell-Like Subpopulations in Venous Malformation
• Stem Cell Origin Differently Affects Bone Tissue Engineering Strategies
• Neural Stem Cell Niche and Egfr Protein
• Stem Cell-Derived Extracellular Vesicles and Immune-Modulation
• Miracles and Tragedies With Stem Cell Treatment
• Sustained Delivery System for Stem Cell-Derived Exosomes
• Stem Cell Research and Its Effects on the Future of Medicine
• The Stem Cell Connection of Pituitary Tumors
• Reproductive Human Stem Cell Cloning
• Stem Cell Activity Towards Tissue Regeneration
• The Signaling Pathways That Control Stem Cell Fate
• Drug Discovery via Human-Derived Stem Cell Organoids
• Therapeutic Cloning and Stem Cell Therapy in South Korea
• The Stem Cell Debate Is Not About Medical Benefits
• Embryonic Stem Cell Research Ethical or Unethical
• Genetic Engineering, Cloning, and Stem Cell Research
• Sickle Cell and the Promise of Stem Cell Therapy
• Mesenchymal Stem Cell Therapy for Aging Frailty
• Christian Ethics and Embryonic Stem Cell Research
• Biotechnology and Stem Cell Research
• Developing Stem Cell-Based Therapies for Neural Repair
• Stem Cell Treatment for Spinal Cord Injuries
• How Do Stem Cells Act as Biorepair Kits?
• How Can Stem Cells Be Used to Treat Human Diseases?
• What Type of Stem Cells Are Isolated From the Inner Mass of Pre-implantation Embryos?
• What Are the Potential Dangers of Stem Cell Technology?
• Why Is Stem Cell Research Controversial?
• Why Is Stem Cell Research Not Allowed Fully in the United States?
• What Is Stem Cell Theory?
• What Are the Arguments in Favor of Stem Cell Therapy?
• What Are Some Applications for Stem Cells?
• What Is the Importance of Stem Cell Transplantation?
• How Do Stem Cells Differentiate?
• Is Stem Cell Therapy the Same as a Bone Marrow Transplant?
• Which Stem Cell Differentiates to Form Neutrophils?
• What Is Somatic Stem Cell Therapy?
• How Do Researchers Turn Stem Cells Into Different Types of Cells in a Laboratory?
• What Do Stem Cells in Your Bone Marrow Eventually Become?
• What Happens When Stem Cells Receive Their Signal?
• Are Somatic Stem Cells Pluripotent?
• What Does It Take To Keep a Stem Cell Alive in the Lab?
• How Do Adult Stem Cells Differ From Pluripotent Stem Cells?
• Why Did the Bush Administration Deny Stem Cell Research?
• Is Animal Stem Cell Research Ethical?
• How Is Stem Cell Research Similar to Developmental Biology?
• Where Do Adult Somatic Stem Cells Originate?
• Which Type of Stem Cell Gives Rise to Red and White Blood Cells?
• Should Stem Cell Research Be Legal?
• What Would Happen if Human Doesn’t Have Stem Cells?
• What Is Using Stem Cells to Produce Healthy Tissues to Treat Degenerative Diseases Called?
• What Is the Difference Between the Different Kinds of Stem Cells?
• What Part of a Human Bone Contains Stem Cells?

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StudyCorgi. (2022, May 10). 100 Stem Cell Research Topics + Examples. https://studycorgi.com/ideas/stem-cell-essay-topics/

"100 Stem Cell Research Topics + Examples." StudyCorgi , 10 May 2022, studycorgi.com/ideas/stem-cell-essay-topics/.

StudyCorgi . (2022) '100 Stem Cell Research Topics + Examples'. 10 May.

1. StudyCorgi . "100 Stem Cell Research Topics + Examples." May 10, 2022. https://studycorgi.com/ideas/stem-cell-essay-topics/.

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StudyCorgi . "100 Stem Cell Research Topics + Examples." May 10, 2022. https://studycorgi.com/ideas/stem-cell-essay-topics/.

StudyCorgi . 2022. "100 Stem Cell Research Topics + Examples." May 10, 2022. https://studycorgi.com/ideas/stem-cell-essay-topics/.

These essay examples and topics on Stem Cell were carefully selected by the StudyCorgi editorial team. They meet our highest standards in terms of grammar, punctuation, style, and fact accuracy. Please ensure you properly reference the materials if you’re using them to write your assignment.

This essay topic collection was updated on December 28, 2023 .

75 Stem Cell Essay Topic Ideas & Examples

🏆 best stem cell topic ideas & essay examples, ⭐ good research topics about stem cell, 👍 simple & easy stem cell essay titles.

• Stem Cell Research D, in the article I am Pro-Life and Oppose Embryonic Stem Cell Research, opposes stem cell research in particular embryonic stem cell research.
• Applying Neural Stem Cells to Counteract Brain Aging Pluripotent stem cells, or PSCs, are the best candidates for in vitro generation and cultivation of neural stem cells. Neural stem cells: Origin, heterogeneity and regulation in the adult mammalian brain.
• Stem Cells Applications in Bone and Tooth Repair and Regeneration It provides examples of scientific research about the application of stem cells in the process of the regeneration of bones and teeth.
• Ethical and Safety Issues of Stem Cell-Based Therapy Ilic and Ogilvie argue that this is a dilemma between the obligation of doctors and scientists to save lives and the need to destroy it in order to obtain stem cells.
• Blood Stem Cell Self-Renewal and Differentiation One of the distinct cells in the blood or hematopoietic stem cell. Due to this functionality, the blood and skin cells’ pose the greatest ability of differentiation and self-renewal.
• Embryonic Stem Cells and Nuclear Transfer Somatic cell dedifferentiation is the “direct reprogramming of an adult somatic cell to return to the state of a pluripotent stem cell” The pros of nuclear transfer are that these embryonic stem cells, which contain […]
• Stem Cell Regenerative Therapy This method is well-studied and has a proven track record of improving spinal stenosis, unlike stem cells. This evidence suggests that stem cells can potentially reverse the degeneration of bone and tissue.
• “What’s the Fuss about Stem Cells?” The primary goal of this essay is to emphasize the importance of the research of the stem cells, provide a precise definition, and explain their functions in the body.
• The Stem Cell Research: Key Aspects In light of the legal aspects of the research, the paper indicates that the human embryo deserves respect just as adults.
• Apple Stem Cell in Skincare Researchers have shown that extracts from Swiss apple, Malus domestica, have regenerative effect on skin, and thus have utilized them in the production of apple stem cells from adult cells.
• Ethical Debate of Stem Cell Research The authors of the article Cogle et al.researched under the auspices of Stem Cell Biology and Regenerative Medicine Program of the University of Florida Shands Cancer Center.
• Stem Cell Research: Some Pros and Cons The science of stem cell treatments, potentially as or more significant than these other innovations, is beginning a new stage of exploration and growth that could be the forerunner of unprecedented cures and therapies.
• Stem Cells Biology: Features and Researchs Stem cells are cells that have the capacity to subdivide into other cells. The second property of stem cells is that they can develop into specialized cells in the differentiation process.
• Nanoscale Silver and Stem Cell Research Whether nanoscale silver or stem cell research, patients realize that the benefits of this technology go without saying. While silver provides many effective applications, stem cell research is the best alternative for curing pancreatic cancer.
• Stem Cell Research from Catholic Perspective The argument exists that because some embryos are created in petri dishes and require implantation into a womb to achieve their full potential that they should not be considered human life, and therefore, can be […]
• Ethics of Stem Cell Research Creating Superhumans Stem cell research is a subject that has generally been absent from the current public and political debates, pushed to the backburner by issues such as the economy, the Iraq War, healthcare, and immigration.
• Stem Cells Therapy of Rheumatoid Arthritis As such, research into the application of the method to the treatment of various conditions is crucial. According to Lillis, the condition causes an inflammation that can extend to the cartilage as well as other […]
• Embryonic Cells in Stem Cell Research Therefore, despite possible ethical concerns associated with the implications of SCR on human nature, I believe that the use of embryonic cells as one of the key aspects of CSR should be promoted as a […]
• Stem Cell Therapies Evaluation The author of this article is Zara Jethani, and she argues that neuroscience is one of the priorities in modern medicine, and this approach to treatment may allow restructuring damaged tissues and cells.
• Stem Cell Treatment, Its Benefits and Efficiency Stem cell treatment is a method that uses the transplantation of cells to facilitate the process of cell regeneration. In conclusion, stem cell therapy is expected to provide a breakthrough in the treatment of adverse […]
• A Promising Prognosis in Stem Cell Therapy The investigation of adult stem cells and induced pluripotent stem cells is of increasing interest as these cells have the most potential for the restoration of myocardial infarction-induced tissue damages.
• Stem Cell Therapy as a Potential Cure for Diabetes The results of a specialized study by Chhabra and Brayman on the treatment of diabetes type 2, which makes 90% to 95% of the cases known globally, has shown that it is viable to treat […]
• Stem Cell Therapy and Diabetes Medical Research This type of diabetes is less common and only occurs during the early stage when the immune system of the body attacks and destroys cells that produce insulin in the pancreas.
• The Controversy Surrounding Adult Stem Cell Research The main fear exposed in the video was that the use of stem cells to treat a disease may result in the seeding of cancer throughout the body.
• Stem Cell Therapy in Colorectal Cancer The novel therapeutic methods used against colorectal cancer stem cells ranges from antibodies and antibody constructs to engineered nanoparticles that target cancerous stem cells in the colon.
• Factors That Influence Stem Cell Research For instance, the GDP of the United States measures the value of goods and services produced within the boundaries of the United States, by people living in the U.S.even if they are not American citizens. […]
• Using Embryonic Stem Cells to Grow Body Parts The use of embryonic stem cells is one of the important medical innovations of the 21st century. The process entails disassembling the embryo to get stem cells that are located in the internal parts of […]
• Kant’s Moral Philosophy on Stem Cell Research In Kant’s own words, “Autonomy of the will is the property that the will has of being a law to itself.[Morality] is the relation of actions to the autonomy of the will […].
• The Research and Use of Stem Cell Embryos Policies of governments across the globe vary on the legality of the prohibited and allowed research and use of stem cell embryos.
• Neural Stem Cells, Viral Vectors in Gene Therapy and Restriction Enzymes The nervous system is comprised of specialized type of cells called Neural Stem Cells. Developmental versatility of plasticity of neural stem cells is important in formation of these different neural cells.
• Stem Cell Research Implementation Nevertheless, the lack of adequate funding from the government has deteriorated the efforts of the researchers in embracing the benefits of this technology.
• Expanding Federal Government Funding of Stem Cell Research This is because stem cell research promises to cure degenerative diseases such as Alzheimer’s and scoliosis but the same time the cure requires the destruction of human embryonic stem cells that can only be had […]
• Adipose-Derived Mesenchymal Stem Cell Application Combined With Fibrin Matrix
• Embryonic Stem Cell Research Provides Revolutionary and Life-Saving Breakthroughs
• Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation
• Ethical and Beneficial Replacement for Embryonic Stem Cell Research
• Biopsy Needle Advancement During Bone Marrow Aspiration and Mesenchymal Stem Cell Concentration
• Autoimmunity Following Allogeneic Hematopoietic Stem Cell Transplantation
• Bioinformatics Analysis and Biomarkers With Cancer Stem Cell Characteristics in Lung Squamous Cell Carcinoma
• Induced Pluripotent Stem Cell-Based Cancer Vaccines
• Embryonic Stem Cell Research: A New Paradigm in Medical Technology
• Advanced Functional Biomaterials for Stem Cell Delivery in Regenerative Engineering and Medicine
• Pragmatic Pluralism: Mutual Tolerance of Contested Understandings Between Orthodox and Alternative Practitioners in Autologous Stem Cell Transplantation
• Allogeneic Hematopoietic Stem Cell Transplantation in a Rare Case of Tonsillar Mast Cell Sarcoma
• Stem Cell Fate Determination During Development and Regeneration of Ectodermal Organs
• Biomimetic Extracellular Matrix Mediated Somatic Stem Cell Differentiation: Applications in Dental Pulp Tissue Regeneration
• Adult Stem Cell and Mesenchymal Progenitor Theories of Aging
• Ethical, Legal, and Social Issues in Genome or Stem Cell Research
• Defective Pulmonary Innate Immune Responses Post-stem Cell Transplantation
• Stem Cell Therapy for Diabetes
• Embryonic Stem Cell Research: The Pandora’s Box of Science
• Bone Marrow Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
• Human Organ Culture: Updating the Approach to Bridge the Gap From in Vitro to in Vivo in Inflammation, Cancer, and Stem Cell Biology
• Adult Stem Cell Therapies for Wound Healing: Biomaterials and Computational Models
• Evaluating the Endocytosis and Lineage-Specification Properties of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Targeted Therapeutic Applications
• Hematopoietic Stem Cell Transcription Factors in Cardiovascular Pathology
• Central Nervous System Complications in Children Receiving Chemotherapy or Hematopoietic Stem Cell Transplantation
• Christian Ethics and Embryonic Stem Cell Research
• Funding Stem Cell Research: A New Field of Innovative Medicine
• Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging
• Stem Cell Research and Its Effects on the Future of Medicine
• Developing Stem Cell-Based Therapies for Neural Repair
• Bioethical and Political Debates Surrounding Embryonic Stem Cell Research
• Autologous Hematopoietic Stem Cell Transplantation for Treatment of Systemic Sclerosis
• Mitochondrial Medicine: Genetic Underpinnings and Disease Modeling Using Induced Pluripotent Stem Cell Technology
• Dental Mesenchymal Stem Cell-Based Translational Regenerative Dentistry: From Artificial to Biological Replacement
• Embryonic Stem Cell Research Could Help Out Many People
• Zinc Maintains Embryonic Stem Cell Pluripotency and Multilineage Differentiation Potential via Akt Activation
• Human Liver Stem Cell-Derived Extracellular Vesicles Prevent Aristolochic Acid-Induced Kidney Fibrosis
• Stem Cell Therapy for Pediatric Traumatic Brain Injury
• Continuous Immune Cell Differentiation Inferred From Single-Cell Measurements Following Allogeneic Stem Cell Transplantation
• Stem Cell-Friendly Scaffold Biomaterials: Applications for Bone Tissue Engineering and Regenerative Medicine
• Biomedicine Essay Topics
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• Chronic Pain Research Ideas
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Stem cells are cells with the potential to develop into many different types of cells in the body. They serve as a repair system for the body. There are two main types of stem cells: embryonic stem cells and adult stem cells.

Stem cells are different from other cells in the body in three ways:

• They can divide and renew themselves over a long time
• They are unspecialized, so they cannot do specific functions in the body
• They have the potential to become specialized cells, such as muscle cells, blood cells, and brain cells

Doctors and scientists are excited about stem cells because they could help in many different areas of health and medical research. Studying stem cells may help explain how serious conditions such as birth defects and cancer come about. Stem cells may one day be used to make cells and tissues for therapy of many diseases. Examples include Parkinson's disease, Alzheimer's disease, spinal cord injury, heart disease, diabetes, and arthritis.

NIH: National Institutes of Health

• Stem Cells: What They Are and What They Do (Mayo Foundation for Medical Education and Research) Also in Spanish
• What Are Stem Cells? (International Society for Stem Cell Research)
• Donating Peripheral Blood Stem Cells (National Marrow Donor Program)
• Donating Stem Cells and Bone Marrow (American Cancer Society) Also in Spanish
• Life after Transplant (National Marrow Donor Program)
• Planning for a Transplant -- Blood Stem Cell (Health Resources and Services Administration)
• Treatment before Transplant (National Marrow Donor Program)
• About Transplantation -- Blood Stem Cell (Health Resources and Services Administration)
• Cord Blood FAQs (National Marrow Donor Program)
• Getting a Stem Cell or Bone Marrow Transplant (American Cancer Society) Also in Spanish
• Nine Things to Know About Stem Cell Treatments (International Society for Stem Cell Research)
• Stem Cell or Bone Marrow Transplant Side Effects (American Cancer Society) Also in Spanish
• Types of Stem Cells (International Society for Stem Cell Research)
• Donation and Transplantation Statistics (Health Resources and Services Administration)

Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)

• Article: DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C....
• Article: Comparative cell viability of dentin-bonding adhesive systems on human dental pulp...
• Article: Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs...
• Stem Cells -- see more articles
• Stem Cell Transplants (For Parents) (Nemours Foundation) Also in Spanish
• Stem Cell Transplants (For Teens) (Nemours Foundation)
• Bone marrow (stem cell) donation (Medical Encyclopedia) Also in Spanish

The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.

Home — Essay Samples — Science — Biology — Stem Cell

Essays on Stem Cell

Brief description of stem cell.

Stem cells are undifferentiated cells with the potential to develop into many different cell types in the body. They are a critical part of the body's repair system and have the potential to treat a wide range of diseases and medical conditions. Stem cell research holds great promise for the future of medicine and has the potential to revolutionize the way we treat various health issues.

Importance of Writing Essays on This Topic

Essays on stem cells are significant for academic and personal exploration because they allow students to delve into the ethical, scientific, and medical implications of this cutting-edge field. By researching and writing about stem cells, students can develop a deeper understanding of the complex issues surrounding this topic and contribute to the ongoing conversation about the potential uses and limitations of stem cell research.

Tips on Choosing a Good Topic

• Consider the ethical implications of stem cell research and its impact on society.
• Explore the latest advancements in stem cell technology and their potential applications in medicine.
• Examine the controversies and debates surrounding the use of embryonic stem cells in research and treatment.

Essay Topics

• The ethical considerations of using embryonic stem cells for medical research.
• The potential applications of stem cell therapy in treating neurodegenerative diseases.
• The role of stem cells in regenerative medicine and tissue engineering.
• The impact of government regulations on stem cell research and its implications for medical advancements.
• The use of induced pluripotent stem cells in disease modeling and drug discovery.
• The controversies surrounding the use of adult stem cells versus embryonic stem cells.
• The potential role of stem cells in personalized medicine and targeted therapies.
• The legal and ethical implications of stem cell banking and its impact on future medical treatments.
• The challenges and opportunities in translating stem cell research into clinical practice.
• The ethical considerations of using stem cells to create human-animal chimeras.

Concluding Thought

Exploring the world of stem cells through essay writing can provide valuable insights into the potential and challenges of this groundbreaking field. By choosing engaging and meaningful topics, students can contribute to the ongoing dialogue about the ethical, scientific, and medical implications of stem cell research.

Thesis Statement for Stem Cell Therapy

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Stem Cells – The Ideal of Medicine

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Stem Cells and Their Types

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Stem Cell Transplantation

Controversial views on stem cell research in america, research on correlation of notch signaling pathway in the prognosis of breast cancer, hematopoietic stem cells specification, mesenchymal stem cells and it's usage in treatment, tissue engineering and stem cells, current research on the ovarian stem cells: a brief review, juvenile diabetes or type 1 diabetes: stem cell therapy.

Stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell.

The term stem cell was coined by Theodor Boveri and Valentin Haecker in late 19th century. Pioneering works in theory of blood stem cell were conducted in the beginning of 20th century by Artur Pappenheim, Alexander Maximow, Franz Ernst Christian Neumann. The first therapy using stem cells was a bone marrow transplant performed by French oncologist Georges Mathé in 1958 on five workers at the Vinča Nuclear Institute in Yugoslavia who had been affected by a criticality accident. The workers all survived.

Self-renewal, Potency, Identification

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• Natural Selection
• Photosynthesis
• Biotechnology
• Space Exploration
• Time Travel
• Isaac Newton

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Embryonic stem cells articles from across Nature Portfolio

Embryonic stem cells are pluripotent cells isolated from the inner cell mass of a blastocyst, the early mammalian embryo that implants into the uterus. Embryonic stem cells self-renew by dividing and can differentiate into any specialised cell of the body, but not extra-embryonic tissues such as the placenta.

Latest Research and Reviews

Enhancing genome editing in hPSCs through dual inhibition of DNA damage response and repair pathways

Precise genome editing is crucial. Here the authors demonstrate that dual inhibition of p53-mediated cell death and distinct activation of the DNA damage repair system upon DNA damage by cytosine base editor (CBE) or prime editor (PE) additively enhanced editing efficiency in hPSCs.

• Ju-Chan Park
• Yun-Jeong Kim
• Hyuk-Jin Cha

Regulation of Myc transcription by an enhancer cluster dedicated to pluripotency and early embryonic expression

MYC regulates numerous genes involved in cell growth and proliferation. Here, Li-Bao et al. study the DNA regions that regulate Myc transcription in early mouse embryos and pluripotent stem cells. They report a specific region with independent modules dedicated to discrete temporal and spatial phases of Myc expression.

• Covadonga Díaz-Díaz
• Miguel Torres

ARTseq-FISH reveals position-dependent differences in gene expression of micropatterned mESCs

Hu et al . describe ARTseq-FISH, a spatial omics method that enables multiplexed detection of mRNAs, proteins and phospho-proteins simultaneously and at the same resolution. The authors investigate gene expression changes in a heterogenous colony of micropatterned mESCs.

• Bob van Sluijs
• Maike M. K. Hansen

The transcription factor OCT6 promotes the dissolution of the naïve pluripotent state by repressing Nanog and activating a formative state gene regulatory network

• Ariel Waisman
• Federico Sevlever
• Santiago Miriuka

ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification

Yang, Golkaram et al. reported that in human embryonic stem cells, cellular crowding leads to the blockade of FGFR1 endocytosis, resulting in a decrease in ETV4 expression. This, in turn, derepresses the neuroectoderm fate.

• Seungbok Yang
• Mahdi Golkaram

Skin graft with dermis and appendages generated in vivo by cell competition

Skin substitutes generated by tissue engineering have limited properties. Here, authors established niche encroachment method. Cell competition enabled skin organogenesis from allogeneic and xenogeneic stem cells on p63 knockout embryos, resulting in a complete skin graft on dermis with hair.

• Hisato Nagano
• Naoaki Mizuno
• Hiromitsu Nakauchi

News and Comment

The rules of the totipotency treasure hunt

Totipotency is the absence of any developmental restriction, a feature naturally found in the early embryo right after fertilization. Generating an in vitro totipotent stem cell model is not a trivial task. For this reason, a set of stringent criteria for the identification of bona fide totipotent stem cells have been proposed.

• Graziano Martello

Nutrient uptake strategies shift during mouse epiblast development

Murine blastocysts and embryonic stem cells mimicking the pre-implantation epiblast import extracellular protein through macropinocytosis and engage a robust lysosomal digestive programme to meet their nutrient demands. We found that as development proceeds, post-implantation epiblast-like cells downregulate protein digestion, increase expression of amino acid transporters and become dependent on soluble amino acids.

The evolution of embryo models

The creation of multiple stem-cell-derived models of mammalian embryogenesis is opening many new doors to study human development and brings a need for scientists to demonstrate responsible dialog over the associated ethical issues.

• Magdalena Zernicka-Goetz

Changing the public perception of human embryology

Human embryology is flourishing thanks to an impetus provided by embryo models formed from stem cells. These scientific advances require meticulous experimental work and a refined ethical framework, but also sensible public communication. Securing public support is essential to achieve societal impact.

• Nicolas C. Rivron
• Alfonso Martinez-Arias
• Kazuto Kato

Pausing pluripotency via RNA methylation

Embryonic diapause in development and paused pluripotency in embryonic stem cells result in a state of hypotranscription through mechanisms that remain unclear. A new study dissects the role of METTL3-deposited global m 6 A RNA methylation in mediating this transcriptional dormancy.

• Baoming Qin

Modeling symmetry breaking

A bioengineering and machine learning-guided approach models human axial development and somitogenesis in vitro.

• Madhura Mukhopadhyay

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