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Leveraging the Crisis for Equity and Access in the Long Term: A Brief Research Report

• Educational Leadership

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For years, crises have occurred in and out of schools. School leaders have had to make meaning of these crises and lead during them. Common rhetoric in today’s media describes the educational inequities children have faced as a result of the current crisis, the COVID-19 pandemic. In an effort to understand how school leaders respond to the COVID-19 pandemic, we spoke directly to principals, listening for ways in which they confronted issues of inequity. Our research was guided by the question: How do principals advance equity for students and families while leading during the COVID-19 crisis? This study focuses on the opportunity’s principals have created during the COVID-19 pandemic to address issues of equity in their schools. We present three main findings resulting from our data analysis. Overall, our findings indicate principals acted upon two primary opportunities for achieving equity in their school community. The findings from our study illustrate two specific opportunities principals were presented with as a result of the crisis to engage in equity responses.

• crisis leadership
• educational leadership
• equity-oriented leadership

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• 10.3389/feduc.2021.618051

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• equity Social Sciences 100%
• leader Social Sciences 31%
• rhetoric Social Sciences 20%
• data analysis Social Sciences 18%
• student Social Sciences 6%

T1 - Leveraging the Crisis for Equity and Access in the Long Term

T2 - A Brief Research Report

AU - Virella, Patricia Marisol

AU - Cobb, Casey

N1 - Publisher Copyright: © Copyright © 2021 Virella and Cobb.

PY - 2021/4/12

Y1 - 2021/4/12

N2 - For years, crises have occurred in and out of schools. School leaders have had to make meaning of these crises and lead during them. Common rhetoric in today’s media describes the educational inequities children have faced as a result of the current crisis, the COVID-19 pandemic. In an effort to understand how school leaders respond to the COVID-19 pandemic, we spoke directly to principals, listening for ways in which they confronted issues of inequity. Our research was guided by the question: How do principals advance equity for students and families while leading during the COVID-19 crisis? This study focuses on the opportunity’s principals have created during the COVID-19 pandemic to address issues of equity in their schools. We present three main findings resulting from our data analysis. Overall, our findings indicate principals acted upon two primary opportunities for achieving equity in their school community. The findings from our study illustrate two specific opportunities principals were presented with as a result of the crisis to engage in equity responses.

AB - For years, crises have occurred in and out of schools. School leaders have had to make meaning of these crises and lead during them. Common rhetoric in today’s media describes the educational inequities children have faced as a result of the current crisis, the COVID-19 pandemic. In an effort to understand how school leaders respond to the COVID-19 pandemic, we spoke directly to principals, listening for ways in which they confronted issues of inequity. Our research was guided by the question: How do principals advance equity for students and families while leading during the COVID-19 crisis? This study focuses on the opportunity’s principals have created during the COVID-19 pandemic to address issues of equity in their schools. We present three main findings resulting from our data analysis. Overall, our findings indicate principals acted upon two primary opportunities for achieving equity in their school community. The findings from our study illustrate two specific opportunities principals were presented with as a result of the crisis to engage in equity responses.

KW - COVID-19

KW - crisis leadership

KW - educational leadership

KW - equity-oriented leadership

KW - principals

UR - http://www.scopus.com/inward/record.url?scp=85104952663&partnerID=8YFLogxK

U2 - 10.3389/feduc.2021.618051

DO - 10.3389/feduc.2021.618051

M3 - Article

AN - SCOPUS:85104952663

SN - 2504-284X

JO - Frontiers in Education

JF - Frontiers in Education

M1 - 618051

Brief Research Report: Anti-SARS-CoV-2 Immunity in Long Lasting Responders to Cancer Immunotherapy Through mRNA-Based COVID-19 Vaccination

Affiliations.

• 1 Infection Biology Laboratory, Department of Medicine and Life Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain.
• 2 Instituto Oncologico Dr Rosell, Hospital Quiron-Dexeus Barcelona, Barcelona, Spain.
• 3 Laboratorio Oncología, Hospital Universitario Dexeus, Pangaea Oncology Lab, Barcelona, Spain.
• 4 Laboratorio Oncología, Germans Trias i Pujol Health Science Insitute and Hospital (IGTP), Badalona, Spain.
• 5 Infectious Diseases Unit, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
• 6 Catalan Institution for Research and Advanced Studies (ICREA) Pg. Lluiís Companys 23, Barcelona, Spain.
• PMID: 35911701
• PMCID: PMC9330498
• DOI: 10.3389/fimmu.2022.908108

Cancer patients (CPs) have been identified as particularly vulnerable to SARS-CoV-2 infection, and therefore are a priority group for receiving COVID-19 vaccination. From the patients with advanced solid tumors, about 20% respond very efficiently to immunotherapy with anti-PD1/PD-L1 antibodies and achieve long lasting cancer responses. It is unclear whether an efficient cancer-specific immune response may also correlate with an efficient response upon COVID-19 vaccination. Here, we explored the antiviral immune response to the mRNA-based COVID-19 vaccine BNT162b2 in a group of 11 long-lasting cancer immunotherapy responders. We analysed the development of SARS-CoV-2-specific IgG serum antibodies, virus neutralizing capacities and T cell responses. Control groups included patients treated with adjuvant cancer immunotherapy (IMT, cohort B), CPs not treated with immunotherapy (no-IMT, cohort C) and healthy controls (cohort A). The median ELISA IgG titers significantly increased after the prime-boost COVID vaccine regimen in all cohorts (Cohort A: pre-vaccine = 900 (100-2700), 3 weeks (w) post-boost = 24300 (2700-72900); Cohort B: pre-vaccine = 300 (100-2700), 3 w post-boost = 8100 (300-72900); Cohort C: pre-vaccine = 500 (100-2700), 3 w post-boost = 24300 (300-72900)). However, at the 3 w post-prime time-point, only the healthy control group showed a statistically significant increase in antibody levels (Cohort A = 8100 (900-8100); Cohort B = 900 (300-8100); Cohort C = 900 (300-8100)) (P < 0.05). Strikingly, while all healthy controls generated high-level antibody responses after the complete prime-boost regimen (Cohort A = 15/15 (100%), not all CPs behaved alike [Cohort B= 12/14 (84'6%); Cohort C= 5/6 (83%)]. Their responses, including those of the long-lasting immunotherapy responders, were more variable (Cohort A: 3 w post-boost (median nAb titers = 95.32 (84.09-96.93), median Spike-specific IFN-γ response = 64 (24-150); Cohort B: 3 w post-boost (median nAb titers = 85.62 (8.22-97.19), median Spike-specific IFN-γ response (28 (1-372); Cohort C: 3 w post-boost (median nAb titers = 95.87 (11.8-97.3), median Spike-specific IFN-γ response = 67 (20-84)). Two long-lasting cancer responders did not respond properly to the prime-boost vaccination and did not generate S-specific IgGs, neutralizing antibodies or virus-specific T cells, although their cancer immune control persisted for years. Thus, although mRNA-based vaccines can induce both antibody and T cell responses in CPs, the immune response to COVID vaccination is independent of the capacity to develop an efficient anti-cancer immune response to anti PD-1/PD-L1 antibodies.

Keywords: COVID-19 vaccination; SARS-CoV-2; cancer; immune checkpoint inhibitors (ICIs); immunotherapy; long lasting responders; mRNA-based vaccines.

Copyright © 2022 Sisteré-Oró, Wortmann, Andrade, Aguilar, Mayo de las Casas, Casabal, Torres, Bona Salinas, Raventos Soler, Arcas, Esparre, Garcia, Valarezo, Rosell, Güerri-Fernandez, Gonzalez-Cao and Meyerhans.

Publication types

• Research Support, Non-U.S. Gov't
• B7-H1 Antigen
• BNT162 Vaccine
• COVID-19 Vaccines* / immunology
• COVID-19* / prevention & control
• Immunoglobulin G
• Immunotherapy
• Neoplasms / therapy
• Research Report
• SARS-CoV-2* / immunology
• Vaccination
• Viral Vaccines*
• mRNA Vaccines / immunology
• COVID-19 Vaccines
• Viral Vaccines
• mRNA Vaccines

• Frontiers in Dental Medicine
• Systems Integration
• Research Topics

Coping with Antimicrobial Resistance in the Context of Dental Medicine

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According to the World Health Organization, antimicrobial resistance (AMR) is ranked in the top 10 global public health threats, because it is a threat to health and development. AMR results in huge costs, causing high mortality and morbidity, and their associated economical costs. It is now consensual that a ...

Keywords : Oral Health, Dentistry, Antibiotics, Antimicrobial Resistance, Alternative Treatments

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